IFN-? limitin: a member of type I IFN with mild lympho-myelosuppression

Positive Feedback Regulation of Type I IFN

Cutting Edge: Type I IFN Reverses Human

Type I IFN protects against murine lupus.

Both the type I (IFN-alpha beta) and type II (IFN-gamma) IFNs have been heavily implicated in the pathogenesis of systemic lupus erythematosus. To test the relative roles of these systems, congenic lupus-prone MRL/CD95(lpr/lpr) (MRL/lpr) mice lacking the type I IFN receptor (IFN-RI), type II IFN receptor (IFN-RII), or both, were derived. As expected, deficiency for IFN-RII protected MRL/lpr mic...

Neutralizing Type I IFN Antibodies Trigger

Murine Dendritic Cell Type I IFN Production